Clinical notes
MSD reliability: The MSD is most useful between 4 and 6 weeks of gestation (before a CRL can be measured). Once an embryo is visible and the crown-rump length can be measured, CRL is the preferred dating method because it is more accurate.
Inter-observer variability: MSD measurements have up to ±19% variability between examiners. Small differences in caliper placement or section plane can shift the MSD by 1–2 mm, which equals 1–2 days in the GA estimate.
Discriminatory zone: When the MSD reaches 25 mm without a visible embryo on transvaginal ultrasound, this is definitive for pregnancy failure (100% positive predictive value). MSD of 16–24 mm without an embryo is suspicious but not diagnostic — a follow-up scan is needed.
Important: This calculator is for educational purposes only and is not medical advice. MSD is an approximation tool for early first-trimester dating and cannot diagnose viability by itself. Always discuss your results with your healthcare provider.