Clinical notes
Threshold for increased risk: A 5-year Gail risk of ≥ 1.67% or a lifetime risk of ≥ 20% is generally considered increased risk. Women in this category may benefit from enhanced screening (e.g., annual MRI in addition to mammography) and discussion of chemoprevention with a healthcare provider.
Model limitations: The Gail model is not appropriate for women with a personal history of breast cancer, DCIS, LCIS, chest radiation for Hodgkin lymphoma, or a known BRCA1/BRCA2 mutation. It also does not include breast density, alcohol use, or other lifestyle factors. The model tends to overestimate risk in younger women and has only modest discriminatory power for individuals.